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工商時報【杜蕙蓉╱台北報導】

免疫療法已成全球新藥研發趨勢,根據IMS Health報告,預估2020年將達308.3億美元,是2014年市場16.9億美元的十幾倍,也吸引全球跨國藥廠爭相競逐。生技大咖認為,台灣應聚焦專攻某幾個領域增加成功率和影響性,除了發展新藥,開發技術平台也是策略。

由台灣生物產業發展協會、生技中心、生控基因、台灣研發型生技新藥發展協會共同舉辦的「新藥研發暨創新免疫醫療論壇」(2)日登場!包括催生25顆新藥上市的Dr.Frank Douglas、中研院基因體中心特聘客座講座教授張子文、台大創新藥物研究中心主任陳基旺,生控總經理暨研發處長吳嘉茂,都分享新藥研發及創新免疫療法策略,生技中心執行長甘良生擔任座談會主持人。

台灣生物產業發展協會理事長李鍾熙表示,免疫療法已被認為具突破性的抗癌策略,透過腫瘤免疫藥物,重新喚醒免疫反應,也引起全球跨國藥廠爭相競逐。根據IMS Health報告,雖然2014年癌症免疫療法市場僅為16.9億美元,但預估2020年將達308.3億美元,成長幅度驚人,台灣學研界及產業界也開始投入此領域。

獲獎無數的前賽諾菲藥廠(Aventis)執行副總裁、首席科學官,目前擔任生控董事兼美國生控執行長,同時也是道格拉斯-阿曼顧問公司 (DAC) 共同創辦人的Frank L. Douglas表示,在台灣,生技是新興的創新產業,投資者要多一點耐心,由於新藥開發耗時久,資金投入龐大,因此應該聚焦專攻某些領域,集合產學研醫的資源增加成功率。此外,除了專注研發一顆新藥,開發一個技術平台同時發展多個新藥是另一種開發策略。

張子文表示,最新的癌症免疫療法發展趨勢有四大方向,包括抗體藥物複合體、雙特異性抗體、免疫檢查點抗體和CAR-T療法等。他也分享最新的製備新型免疫治療藥物的技術平台。

吳嘉茂指出,生控的免疫平台可以發展各個癌症及感染性疾病的創新療法,做到主動式T細胞免疫反應。規劃中的產品線,包括子宮頸癌及其癌前病變免疫療法、HPV16/18型子宮頸癌雙價、B型肝炎、C型肝炎及肝癌,以及肺癌免疫療法等正在臨床前實驗階段。

下面附上一則新聞讓大家了解時事

印地安人隊菜鳥投手Ryan Merritt表現令人驚奇,在美國聯盟冠軍賽第五戰帶領印地安人隊3比0擊敗藍鳥隊,以四勝一敗的戰績挺進世界大賽,這是印地安人隊史自1997年之後再度打進世界大賽。

印地安人隊最後一次拿到世界大賽冠軍,已是68年前1948年的事了,期間印地安人隊三度打進世界大賽,但最後都功虧一簣,分別是1954年、1995年及1997年,今年印地安人隊再次打進世界大賽,而且台北時間26日將在克利夫蘭印地安人隊主場進行世界大賽的第一戰,這是史上第一次。

印地安人隊此戰由24歲的菜鳥投手Merritt先發,他生涯僅在大聯盟出賽4場,投11局,雖然如此他卻表現精采,此戰Merritt先發4.1局被擊出2支安打沒失分,三振3次、沒保送,接下來Bryan Shaw投1局,Andrew Miller投2.2局,Cody Allen投最後一局都沒失分,4名投手聯手完封藍鳥隊。

印地安人隊1局上Francisco Lindor、Mike Napoli連續安打先攻下1分,穩住軍心,3局上Carlos Santana轟陽春彈,4局上Coco Crisp再轟陽春砲,就這樣,印地安人隊雖然只擊出6支安打,但仍可打敗藍鳥隊。

藍鳥隊Marco Estrada先發6局被擊出5支安打包括2轟,失3分、2分責失,在美聯冠軍賽先發兩場都吞敗投。

★更多相關新聞

印地安人菜鳥投手令人驚奇的一戰
Miller獲選美聯冠軍賽MVP首選>印地安人總教練超狂 比賽中對攝影機比中指!
回魂的希爾:這是我生涯最重要的一戰
前洋基強投黑田宣布 日本一後退休

點選以在新視窗中開啟內容。

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  • 最便宜 weapon.?

    Chicago boasts a deep starting rotation that led the majors with a 2.96 ERA during the regular season. Between Jon Lester — who's posted a 0.86 ERA in three postseason games — Jake Arrieta and Kyle Hendricks, the Cubs are set.?

    The Indians had a brilliant starting rotation of their own at one point this season, but lost two of their talented arms to injury. There are murmurs of one of them returning, but more on that later.

    Aside from Game 1 starter and former Cy Young Award winner Corey Kluber, the Indians have relied on good — but not elite — starting pitchers who turn in gutsy performances.?

    Corey Kluber won 18 games in 2016.Image: Maddie Meyer/Getty ImagesJosh Tomlin is largely untested. Trevor Bauer bled himself off the mound last week. Ryan Merritt has two major league starts to his name.

    Still, the Indians starting rotation has an impressive 1.86 ERA this postseason.

    But don't let the numbers fool you. Chicago has an edge here.?

    4. Comeback kids

    This World Series will feature elite relief pitching, the best of the best. Games will surely come down to the late innings.

    But here's something to chew on.?

    This postseason, the Cubs have scored 17 runs in the seventh inning or later, the best of any team. They've thrived on comeback wins, and never seem to go down quietly.

    Image: Jamie Squire/Getty ImagesHow many have the Indians scored in the seventh or later?

    Zero.?

    Cleveland appears incapable of putting runs on the board with their backs against the wall. Their game plan, as mentioned, is to get an early lead and turn things over to the bullpen.

    That might not work against a team like the Cubs.?

    Chicago's bullpen is beatable, but it's still formidable in the late innings, a time when the Indians' bats seem to be incredibly weak.?

    5. Reviving the dead

    Chicago won more than 100 games without Kyle Schwarber, one of the Cub's elite young superstars. Schwarber hit five postseason home runs last year, but tore his ACL just two games into this season.?

    Now, there's talk he might be back.?

    Since coming 最新出版off the disabled list on Saturday, Schwarber has been getting back into playing shape in the Arizona Fall League (AFL). Depending on his performance in an AFL game Monday night, the Cubs could activate him for a designated hitter role in the World Series on Tuesday.?

    There's sure to be rust, but if Schwarber performs anything like the player he was in 2015, he could be a difference-maker.?

    For Cleveland, it's looking like starting pitcher Danny Salazar will return as well.

    The All-Star right-hander, who struck out more than 10 batters per nine innings during the regular season, has been sidelined with a forearm strain since Sept. 9. It's unclear whether or not Salazar will start, considering the long layover, but he would bring stability to a starting rotation that desperately needs it.?

    Both teams aren't taking any chances. They want their best lineups on the field.

    Image: Maddie Meyer/Getty ImagesThis World Series figures to be epic, not only because of the historical context, but because of how each team's strengths counter the other's. Chicago's bats are scary, but Cleveland's pitching is hot. The Indians' bullpen is ferocious, but the Cubs know how to score late.?

    Regardless, one of these long-suffering franchises will see relief soon. A historic championship drought will be quenched with a champagne shower.?

    The loser? Well, they're already used to losing, and can wait just a little longer.?">








If you don't like baseball, watch baseball, or know what baseball is, know this — the 2016 World Series is different.?

When the Cleveland Indians host the Chicago Cubs in a best-of-seven series

... 較多If you don't like baseball, watch baseball, or know what baseball is, know this — the 2016 World Series is different.?

When the Cleveland Indians host the Chicago Cubs in a best-of-seven series beginning Tuesday night, we won't just witness another run-of-the-mill Fall Classic. This year's matchup is steeped in history, characterized by decades of suffering, and features two teams who know a whole lot about losing.?

By the end of this World Series, one city will hoist the championship trophy for the first time in a very, very, long time.?

SEE ALSO: 折扣The dark side of a feel-good World Series

The Cubs haven't won a World Series since 1908, the longest championship drought in North American professional sports. They haven't even been to a World Series since 1945.?

Chicago's franchise is supposedly cursed, and the years of bad luck and losing seasons prove it.?

But a revamped front office and minor-league farm system have turned the Cubs from lovable losers to a national powerhouse. They showed up at Spring Training with the best odds of winning the World Series and led baseball with 103 wins during the regular season. ?

It's easy to root for this year's Cubs, until you remember who's in the other corner.

Image: Jamie Squire/Getty Images

The Indians haven't won a World Series since 1948, the second longest championship drought in baseball. Cleveland stumbled through the 1970s and '80s, failing to make the postseason every season in a 24-year span. Its last World Series appearances — both losses, of course — came in 1995 and 1997.?

The history of this World Series is huge, and each team's drought will be hyped constantly. But there's more to this matchup.

So, if you're just tuning in, here are our five biggest storylines to watch during the 112th World Series.?

1. Battle of the bullpens



The Cubs and Indians have one very specific thing in common —?in July, they both picked up two of the best relief pitchers in baseball, courtesy of the New York Yankees. The Indians, who traded for Andrew Miller, and the Cubs, who traded for Aroldis Chapman, understood the value of a shut-down bullpen in the postseason, and made sure to stock up on elite relievers.?

Andrew Miller has been unbeatable.

Image: Elsa/Getty Images

The results have been undeniable.?

Miller struck out 21 batters in 11.2 scoreless postseason innings for the Indians, earning MVP honors in the American League Championship Series. He's at the helm of a monster bullpen with a 1.67 ERA in the playoffs.?

Cleveland's strategy this postseason is simple —?get an early lead and let the bullpen save it.?

Though the Cubs' bullpen might not have the flashiest postseason numbers this year — a 3.53 ERA and a couple blown saves — it still features Chapman, who fires 100-mph fastballs right by hitters on a regular basis.?



Image: mlb

Keep an eye on the bullpen. This series could hinge on the guys emerging from it.?

2. The fountain of youth



You can bet Fox announcers will constantly tout the young talent of both World Series teams, particularly Chicago.?

The average age of the Cubs infield — featuring All-Star Addison Russell, NLCS co-MVP Javier Baez, 2015 Rookie of the Year Kris Bryant and MVP candidate Anthony Rizzo — is 24 years old.?

Russell and Baez are only 22 and 23, respectively. They epitomize the Cubs' philosophy of developing young superstars and complimenting them with big-budget free agent signings.?

Clearly, that model has worked.?

Javier Baez was the Cubs' co-MVP of the NLCS.

Image: mlb

The Indians have shallower pockets, and couldn't afford to take the powerhouse approach. Instead, Cleveland relies on contributions from more frugal pick-ups like Rajai Davis and Mike Napoli.?

They still boast a solid young core that features All-Star shortstop Francisco Lindor (22), José Ramirez (24) and rookie Tyler Naquin (25). Rookie starting pitcher Ryan Merritt (24) made only one major league start before helping the Indians clinch a World Series berth last week.?

For a World Series soaked in historical context, this Fall Classic belongs to the kids.?

3. It starts with starting pitching



With all eyes on the bullpen, starting pitching購物 could be the Cubs' not-so -secret weapon.?

Chicago boasts a deep starting rotation that led the majors with a 2.96 ERA during the regular season. Between Jon Lester — who's posted a 0.86 ERA in three postseason games — Jake Arrieta and Kyle Hendricks, the Cubs are set.?

The Indians had a brilliant starting rotation of their own at one point this season, but lost two of their talented arms to injury. There are murmurs of one of them returning, but more on that later.

Aside from Game 1 starter and former Cy Young Award winner Corey Kluber, the Indians have relied on good — but not elite — starting pitchers who turn in gutsy performances.?

Corey Kluber won 18 games in 2016.

Image: Maddie Meyer/Getty Images

Josh Tomlin is largely untested. Trevor Bauer bled himself off the mound last week. Ryan Merritt has two major league starts to his name.

Still, the Indians starting rotation has an impressive 1.86 ERA this postseason.

But don't let the numbers fool you. Chicago has an edge her開箱文e.?

4. Comeback kids



This World Series will feature elite relief pitching, the best of the best. Games will surely come down to the late innings.

But here's something to chew on.?

This postseason, the Cubs have scored 17 runs in the seventh inning or later, the best of any team. They've thrived on comeback wins, and never seem to go down quietly.

Image: Jamie Squire/Getty Images

How many have the Indians scored in the seventh or later?

Zero.?

Cleveland appears incapable of putting runs on the board with their backs against the wall. Their game plan, as mentioned, is to get an early lead and turn things over to the bullpen.

That might not work against a team like the Cubs.?

Chicago's bullpen is beatable, but it's still formidable in the late innings, a time when the Indians' bats seem to be incredibly weak.?

5. Reviving the dead



Chicago won more than 100 games without Kyle Schwarber, one of the Cub's elite young superstars. Schwarber hit five postseason home runs last year, but tore his ACL just two games into this season.?



Now, there's talk he might be back.?

Since coming off the disabled list on Saturday, Schwarber has been getting back into playing shape in the Arizona Fall League (AFL). Depending on his performance in an AFL game Monday night, the Cubs could activate him for a designated hitter role in the World Series on Tuesday.?

There's sure to be rust, but if Schwarber performs anything like the player he was in 2015, he could be a difference-maker.?

For Cleveland, it's looking like starting pitcher Danny Salazar will return as well.

The All-Star right-hander, who struck out more than 10 batters per nine innings during the regular season, has been sidelined with a forearm strain since Sept. 9. It's unclear whether or not Salazar will start, considering the long layover, but he would bring stability to a starting rotation that desperately needs it.?

Both teams aren't taking any chances. They want their best lineups on the field.

Image: Maddie Meyer/Getty Images

This World Series figures to be epic, not only because of the historical context, but because of how each team's strengths counter the other's. Chicago's bats are scary, but Cleveland's pitching is hot. The Indians' bullpen is ferocious, but the Cubs know how to score late.?

Regardless, one of these long-suffering franchises will see relief soon. A historic championship drought will be quenched with a champagne shower.?

The loser? Well, they're already used to losing, and can wait just a little longer.?

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2016年10月25日週二 台北標準時間上午6時37分





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